patch-clamp micromanipulator pcs-5000 (Burleigh Instruments)
90
Structured Review
Burleigh Instruments
patch-clamp micromanipulator pcs-5000
Patch Clamp Micromanipulator Pcs 5000, supplied by Burleigh Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/patch+clamp+micromanipulator/piezoelectric+manipulator+pcs+5000/pmc08931764__ja2c00581_si_001-19-12-15
Average 90 stars, based on 1 article reviews
Patch Clamp Micromanipulator Pcs 5000, supplied by Burleigh Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/patch+clamp+micromanipulator/piezoelectric+manipulator+pcs+5000/pmc08931764__ja2c00581_si_001-19-12-15
Average 90 stars, based on 1 article reviews
patch-clamp micromanipulator pcs-5000 - by Bioz Stars,
2026-10
90/100 stars
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Patch Clamp:Article Title: Action Spectra of Zebrafish Cone Photoreceptors Article Snippet: The electrodes were placed in a Article Title: On the Action of General Anesthetics on Cellular Function: Barbiturate Alters the Exocytosis of Catecholamines in a Model Cell System. Article Snippet: General anesthetics are essential in many areas, however, the cellular mechanisms of anesthetic-induced amnesia and unconsciousness are incompletely understood.. Exocytosis is the main mechanism of signal transduction and neuronal communication through the release of chemical transmitters from vesicles to the extracellular environment.. Here, we use disk electrodes placed on top of PC12 cells to show that treatment with barbiturate induces fewer molecules released during exocytosis and changes the event dynamics perhaps by inducing a less stable fusion pore that is prone to close faster during partial exocytosis. Article Title: Combined electrochemistry and mass spectrometry imaging to interrogate the mechanism of action of modafinil, a cognition-enhancing drug, at the cellular and sub-cellular level Article Snippet: The electrode was gently settled on the membrane of a PC12 cell by a Article Title: DMSO Chemically Alters Cell Membranes to Slow Exocytosis and Increase the Fraction of Partial Transmitter Released. Article Snippet: Dimethyl sulfoxide (DMSO) is frequently used as a solvent in biological studies and as a vehicle for drug therapy; but the side effects of DMSO, especially on the cell environment, are not well understood, and controls with DMSO are not neutral at higher concentrations.. Herein, electrochemical measurement techniques are applied to show that DMSO increases exocytotic neurotransmitter release, while leaving vesicular contents unchanged.. In addition, the kinetics of release from DMSOtreated cells are faster than that of untreated ones. Article Title: Concentration of stimulant regulates initial exocytotic molecular plasticity at single cells Article Snippet: For single cell exocytosis, a disk carbon-fiber microelectrode was moved slowly by a Article Title: Anionic Species Regulate Chemical Storage in Nanometer Vesicles and Amperometrically Detected Exocytotic Dynamics Article Snippet: For SCA, a disk carbon fiber microelectrode was moved slowly by a Article Title: Cones perform a non-linear transformation on natural stimuli Article Snippet: The electrodes were placed in a Article Title: Cones perform a non-linear transformation on natural stimuli. Article Snippet: The electrodes were placed in a Membrane:Article Title: Action Spectra of Zebrafish Cone Photoreceptors Article Snippet: The electrodes were placed in a Article Title: On the Action of General Anesthetics on Cellular Function: Barbiturate Alters the Exocytosis of Catecholamines in a Model Cell System. Article Snippet: General anesthetics are essential in many areas, however, the cellular mechanisms of anesthetic-induced amnesia and unconsciousness are incompletely understood.. Exocytosis is the main mechanism of signal transduction and neuronal communication through the release of chemical transmitters from vesicles to the extracellular environment.. Here, we use disk electrodes placed on top of PC12 cells to show that treatment with barbiturate induces fewer molecules released during exocytosis and changes the event dynamics perhaps by inducing a less stable fusion pore that is prone to close faster during partial exocytosis. Article Title: Combined electrochemistry and mass spectrometry imaging to interrogate the mechanism of action of modafinil, a cognition-enhancing drug, at the cellular and sub-cellular level Article Snippet: The electrode was gently settled on the membrane of a PC12 cell by a Article Title: DMSO Chemically Alters Cell Membranes to Slow Exocytosis and Increase the Fraction of Partial Transmitter Released. Article Snippet: Dimethyl sulfoxide (DMSO) is frequently used as a solvent in biological studies and as a vehicle for drug therapy; but the side effects of DMSO, especially on the cell environment, are not well understood, and controls with DMSO are not neutral at higher concentrations.. Herein, electrochemical measurement techniques are applied to show that DMSO increases exocytotic neurotransmitter release, while leaving vesicular contents unchanged.. In addition, the kinetics of release from DMSOtreated cells are faster than that of untreated ones. Article Title: Concentration of stimulant regulates initial exocytotic molecular plasticity at single cells Article Snippet: For single cell exocytosis, a disk carbon-fiber microelectrode was moved slowly by a Article Title: Anionic Species Regulate Chemical Storage in Nanometer Vesicles and Amperometrically Detected Exocytotic Dynamics Article Snippet: For SCA, a disk carbon fiber microelectrode was moved slowly by a Article Title: Cones perform a non-linear transformation on natural stimuli Article Snippet: The electrodes were placed in a Article Title: Cones perform a non-linear transformation on natural stimuli. Article Snippet: The electrodes were placed in a Cytometry:Article Title: Action Spectra of Zebrafish Cone Photoreceptors Article Snippet: The electrodes were placed in a Article Title: On the Action of General Anesthetics on Cellular Function: Barbiturate Alters the Exocytosis of Catecholamines in a Model Cell System. Article Snippet: General anesthetics are essential in many areas, however, the cellular mechanisms of anesthetic-induced amnesia and unconsciousness are incompletely understood.. Exocytosis is the main mechanism of signal transduction and neuronal communication through the release of chemical transmitters from vesicles to the extracellular environment.. Here, we use disk electrodes placed on top of PC12 cells to show that treatment with barbiturate induces fewer molecules released during exocytosis and changes the event dynamics perhaps by inducing a less stable fusion pore that is prone to close faster during partial exocytosis. Article Title: Combined electrochemistry and mass spectrometry imaging to interrogate the mechanism of action of modafinil, a cognition-enhancing drug, at the cellular and sub-cellular level Article Snippet: The electrode was gently settled on the membrane of a PC12 cell by a Article Title: DMSO Chemically Alters Cell Membranes to Slow Exocytosis and Increase the Fraction of Partial Transmitter Released. Article Snippet: Dimethyl sulfoxide (DMSO) is frequently used as a solvent in biological studies and as a vehicle for drug therapy; but the side effects of DMSO, especially on the cell environment, are not well understood, and controls with DMSO are not neutral at higher concentrations.. Herein, electrochemical measurement techniques are applied to show that DMSO increases exocytotic neurotransmitter release, while leaving vesicular contents unchanged.. In addition, the kinetics of release from DMSOtreated cells are faster than that of untreated ones. Article Title: Concentration of stimulant regulates initial exocytotic molecular plasticity at single cells Article Snippet: For single cell exocytosis, a disk carbon-fiber microelectrode was moved slowly by a Article Title: Anionic Species Regulate Chemical Storage in Nanometer Vesicles and Amperometrically Detected Exocytotic Dynamics Article Snippet: For SCA, a disk carbon fiber microelectrode was moved slowly by a Article Title: Cones perform a non-linear transformation on natural stimuli Article Snippet: The electrodes were placed in a Article Title: Cones perform a non-linear transformation on natural stimuli. Article Snippet: The electrodes were placed in a |
![Left: Overview of the experimental setup showing perfusion inflow and outflow tubing, a low-magnification objective, a high-magnification water-immersion objective, and both white and infrared (IR)-LEDs mounted on a <t>micromanipulator.</t> The LEDs should be connected to an adjusted power supply unit and positioned so that their beams strike the plane of the experimental chamber at a 10–20° angle. Note that the LEDs must remain above the bath solution and should not be submerged. Right: Overview of spinal cord preparation in the experimental chamber. The ex vivo spinal cord preparation is affixed to a metal plate at an approximately 45° angle so that the dorsal horn is on top. The spared dorsal root is connected to a suction electrode and is slightly pulled to reveal the underlying dorsal horn. Modified from [17].](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_2122/pmc12602122/pmc12602122__BioProtoc-15-21-5483-g013.jpg)